Both Methadone and Suboxone, a buprenorphine treatment, are designed to provide the body the required level of opioids to eliminate withdrawal symptoms. But, they have very different effects. For example, Methadone is a long lasting opioid with psychoactive properties. It is necessary to have the drug administered on a daily basis to keep the proper opioid levels. Suboxone, or other forms of buprenorphine, is a short term opioid with no psycho activity and is self-administered at home. Traditionally, Methadone is a lifelong treatment, while Suboxone treatment can be reduced over time.